Chronic Exposure to Arsenic in Drinking Water Causes Alterations in Locomotor Activity and Decreases Striatal mRNA for the D2 Dopamine Receptor in CD1 Male Mice

Table 4

Regional brain content of monoamines (ng/mg protein) in striatum and frontal cortex of mice exposed to 0.5 or 5.0 mg As/L of drinking water for six months.

Brain region	Treatment	DA	DOPAC	HVA	5-HT	5-HIAA	DOPAC/DA
Striatum	Control	80.60 ± 13.00	5.29 ± 1.56	4.22 ± 0.95	5.71 ± 1.26	2.87 ± 0.57	0.06 ± 0.01
	0.5 mg As/L	91.22 ± 19.37	2.86 ± 0.04	4.20 ± 0.70	5.19 ± 1.36	2.58 ± 0.48	0.06 ± 0.01
	5.0 mg As/L	55.70 ± 6.83	3.70 ± 0.83	3.35 ± 0.46	5.80 ± 1.05	2.29 ± 0.35	0.07 ± 0.01
Frontal cortex	Control	1.17 ± 0.31	ND	ND	4.37 ± 1.51	2.42 ± 0.72	—
	0.5 mg As/L	1.86 ± 0.39	ND	ND	6.18 ± 1.16	1.88 ± 0.42	—
	5.0 mg As/L	1.53 ± 0.23	ND	ND	8.06 ± 2.17	2.22 ± 0.35	—

Values are mean ± SEM ( = 7–13) and are reported as ng/mg of protein. DA, dopamine; DOPAC, 3,4-dihydroxyphenylacetic acid; HVA, homovanillic acid; 5-HT, serotonin; 5-HIAA, 5-hydroxyindoleacetic acid. ND: not detected.