Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Figure 4

Photomicrographs of renal cortex immune stained for TNFα of: (a), (b), and (c), control, DLD, and DHD groups, respectively, showing negative immunoreactivity. (d) DOX treated group showing extensive expression in the renal glomeruli and renal tubules. (e) DOX/DLD group showing moderate expression within the glomeruli and the renal tubules. (f) DOX/DHD group showed marked improvement with no expression in glomeruli and renal tubules. The expression is mainly cytoplasmic, but with some immunopositive nuclei. Immunohistochemistry counter stained with H&E ×400. Bar = 20 μ.

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