Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Table 3

Scoring of morphological changes observed in control and experimental groups by light microscope ().

Findings	Control group	DLD group	DHD group	DOX treated group	DOX/DLD group	DOX/DHD group
(i) Glomerular vacuolations	−	−	−	++++	+	+
(ii) Enlarged renal corpuscles	−	−	−	++++	+	−
(iii) Tubular cells vacuolations	−	+	−	++++	+	+
(iv) Lumen widening	−	−	−	++++	+	−
(v) Distortion and Degeneration	−	−	−	++++	+	−
(vi) Casts	−	−	−	−	−	−

Animal groups tested are control untreated group, animals treated with diacerein (25 mg/kg/day, DLD) and diacerein (50 mg/kg/day, DHD), respectively, and animals treated with doxorubicin (DOX, 15 mg/kg), or with DOX together with low or high dose of diacerein (DOX/DLD or DOX/DHD), respectively.
Normal (−), in-between normal and mild (+), mild (++), moderate (+++), and severe (++++) [9].