Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat

<div>Individual FVIII clotting activity versus time in week 52 in male (triangles) and female (circles) Rowett nude rats following an intravenous dose of 150 IU/kg (Group 3), 500 IU/kg (Group 4), or 1200 IU/kg (Group 5) (sparse sampling with two samples per animal, in general<i> n</i> = 2-3 per sex per time point).</div>

Journal of Toxicology

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Figure 1

Figure 1: Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat 