Research Article
Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat
Table 6
Anti-N8-GP antibodies detected in animals during the dosing phase.
| Group | Dose (IU/kg/fourth day) | Anti-N8-GP antibodies (positive/total) | 26-week study (week 26) | 52-week study (week 26) | 52-week study (week 52) |
| 2 | 50 | 2/36 | 3/42 | 2/36 | 3 | 150 | 1/34 | 1/40 | 0/35 | 4 | 500 | 2/35 | 0/38 | 1/34 | 5 | 1200 | 0/34 | 2/39 | 1/35 |
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