Assessment of Acute and Chronic Toxicity in Wistar Rats (Rattus norvegicus) and New Zealand Rabbits (Oryctolagus cuniculus) of an Enriched Polyphenol Extract Obtained from Caesalpinia spinosa

Table 2

Absolute and relative weight of liver, left kidney, left adrenal, and spleen in rats and rabbits.

	Sex	Group	N	Liver		Kidney L		Adrenal L		Spleen
				AW (g)	RW (%)	AW (g)	RW (%)	AW (g)	RW (%)	AW (g)	RW (%)
Rats	Females	Test	3	9.31 ± 0.73	3.51 ± 0.08	0.99 ± 0.02	0.38 ± 0.02	0.0483 ± 0.0036	0.0182 ± 0.0012	0.56 ± 0.10	0.21 ± 0.02
		Control	5	8.24 ± 0.61	3.29 ± 0.31	0.91 ± 0.10	0.36 ± 0.04	0.0370 ± 0.042	0.0148 ± 0.0023	0.49 ± 0.10	0.19 ± 0.03
	value			0.07	0.22	0.15	0.63	0.008	0.06	0.36	0.49
	Males	Test	3	16.63 ± 1.88	3.05 ± 0.29	1.55 ± 0.23	0.28 ± 0.03	0.0338 ± 0.0038	0.0062 ± 0.006	0.81 ± 0.12	0.15 ± 0.01
		Control	5	17.01 ± 1.61	3.35 ± 0.38	1.58 ± 0.07	0.31 ± 0.03	0.0336 ± 0.0083	0.0065 ± 0.0011	0.80 ± 0.12	0.16 ± 0.02
	value			0.77	0.29	0.88	0.29	0.97	0.72	0.87	0.57
Rabbits	Test		7	84.13 ± 11.31	1.925 ± 0.357	9.66 ± 0.83	0.221 ± 0.031	0.256 ± 0.069	0.006 ± 0.002	2.31 ± 0.55	0.052 ± 0.010
	Control		5	91.16 ± 13.90	1.801 ± 0.088	10.85 ± 1.11	0.216 ± 0.015	0.302 ± 0.067	0.006 ± 0.001	2.43 ± 0.56	0.048 ± 0.010
	value			0.36	0.41	0.06	0.74	0.28	0.8	0.71	0.52