Assessment of Acute and Chronic Toxicity in Wistar Rats (Rattus norvegicus) and New Zealand Rabbits (Oryctolagus cuniculus) of an Enriched Polyphenol Extract Obtained from Caesalpinia spinosa
Table 4
Effects of P2Et extract on hematological parameters in rats following 180 days of administration.
Parameters (reference values)
Group
value
Test (N = 6)
Control (N = 8)
Erythrogram
Erythrocyte (6.6 to 9.0 million/mm3)
6.62 ± 0.21
6.71 ± 0.52
0.69
Hemoglobin (13.2 to 16.4 g/dL)
14.43 ± 0.51
14.08 ± 0.83
0.37
Hematocrit (41.1 to 51.1%)
43.87 ± 2.12
43.25 ± 2.60
0.56
MCV (52.5 to 65.4 μ3)
66.33 ± 4.32
64.54 ± 2.41
0.34
MCH (16.5 to 21.3 pg)
21.83 ± 0.85
21.01 ± 0.93
0.12
MCHC (30.2 to 34.5 g/dL)
32.93 ± 1.07
32.58 ± 0.84
0.49
Leucogram
Leukocytes (7.3 to 12.6 thousands/mm3)
5.52 ± 1.61
6.14 ± 1.33
0.44
Neutrophil (28 to 44%)
39.17 ± 7.55
37.88 ± 3.94
0.68
Eosinophil (1 to 5%)
0.67 ± 0.82
0.50 ± 0.76
0.70
Lymphocytes (39 to 72%)
57.83 ± 7.36
59.13 ± 3.80
0.68
Monocytes (3 to 12%)
2.33 ± 1.21
2.50 ± 1.20
0.80
Coagulogram
PT (seconds)
16.94 ± 1.50
16.14 ± 0.63
0.20
Platelets (0.84 to 1.24 million/mm3)
0.73 ± 0.16
0.73 ± 0.14
0.99
PPT (seconds)
21.16 ± 4.36
25.84 ± 4.51
0.09
Total protein
6.8 to 8.7 g/dL
7.00 ± 0.22
7.13 ± 0.38
0.49
N: number of animals in the group, data expressed as mean ± standard deviation. MCV: mean corpuscular volume; MCH: mean corpuscular hemoglobin; MCHC: mean corpuscular hemoglobin concentration (MCHC); PT: prothrombin time; PPT: partial thromboplastin time.
