Research Article
NETosis Secondary to the Use of Levamisole-Adulterated Cocaine: A Likely Underlying Mechanism of Vasculopathy
Table 1
Sociodemographic and clinical characteristics of patients with LAC-associated vasculitis (n = 25).
| Sociodemographic data, n (%) |
| Age (years) | 34 [25–51] | Sex | Female | 4 (16) | Male | 21 (84) | Substance abuse | Alcohol | 16 (64) | Marijuana | 19 (71) | Tobacco | 19 (71) |
| Clinical and histopathological findings |
| Necrosis of earlobes | 20 (80) | Arthralgias/arthritis | 16 (64) | Skin ulcers | 9 (36) | Autoimmune hemolytic anemia | 7 (28) | Nephritis | Immune complexes | 9 (36) | Other nephritis | 6 (24) | Pseudovasculitis | 4 (16) | Pyoderma gangrenosum | 3 (12) | Vasculitis | Leukocytoclastic | 2 (8) | Vasculopathies | Thrombotic | 2 (8) |
| Laboratory findings |
| Neutropenia | 4 (16) | Hypocomplementemia | C3 | 13 (52) | C4 | 3 (12) | Autoantibodies | ANAs | 14 (56) | ANCAs | 24 (92) | p-ANCA | 9 (36) | Anti-MPO | 16 (64) | Anti-PR3 | 7 (28) | Creatinine (mg/dl) | PWN | 1.8 [1.1–4.0] | PWON | 0.7 [0.6–0.8] | Blood count | Hemoglobin | PWN | 8.8 [7.6–12] | PWON | 10.6 [9.9–13.4] | VSG | PWN | 81 [52–103] | PWON | 87 [59.5–120] | Platelets | PWN | 342000 [239000–425000] | PWON | 407000 [236750–461500] | Neutrophils | PWN | 3310 [2100–5550] | PWON | 3190 [2697–6388] | Lymphocytes | PWN | 1180 [820–2300] | PWON | 1230 [675–2059] |
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Median and range. Median and interquartile range. |