Structure-Function of Falcipains: Malarial Cysteine Proteases

Figure 2

Domains of falcipain-2: schematic diagram showing different domains of falcipain-2. Prodomain is made up of cytoplasmic, transmembrane, luminal, and inhibitory domains. The mature domain has refolding domain, hemoglobin (Hb) binding domain, and catalytic triad residues (Cys, His, Asn). The conserved residues (Phe¹⁶⁵, Phe¹⁶⁸) present in inhibitory domain are labeled with asterisks.