345195.fig.006a
(a)
345195.fig.006b
(b)
Figure 6: (a) 3D structure of falcipain-2-cystatin complex. Cystatin is colored in orange, and falcipain-2 protease is colored in green. Refolding domain and hemoglobin binding domain highlighted in pink and salmon, respectively. The shaded area in the figure corresponds to the size of human cathepsin H, superimposed on falcipain-2 in light blue. (b) The catalytic Cys, His, and Asn are depicted in stick mode in green, and substrate binding pockets are labeled P3 to P1′. Ile-68 at P2 is depicted in stick mode to illustrate a slight protrusion in the S2 pocket of falcipain-2.