345195.fig.008a
(a)
345195.fig.008b
(b)
Figure 8: Chemical structures of E-64 and leupeptin. The positions of P1, P2, P3 of the inhibitors that occupy the S1, S2, and S3 subsites of enzyme, respectively, are labeled. Inhibitor and enzyme groups which are involved in covalent bond formation are shown in red.