Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog

Table 1

Frequencies of cytokine and iNOS expressions determined by reverse transcriptase PCR in 12 asymptomatic dogs (with high parasite load in viscera) infected with L. infantum amastigotes, six months postinfection.

Tissue/organ	INF-𝛾 (%)	TGF-𝛽 (%)	TNF-𝛼 (%)	IL-10 (%)	iNOS (%)
Peripheral blood	0	91.66	66.66	0	0
Lymph node	0	36.36	54.54	81.81	36.36
Liver	9	18.16	0	18.19	18.19
spleen	11.11	11.11	0	33.33	33.33
Bone marrow	25	66.66	41.66	100	75

INF-γ: interferon-gamma; TGF-𝛽: transforming growth factor-beta; TNF-𝛼: tumour necrosis factor-alpha; IL-10: interleukin-10; iNOS: inducible nitric oxide synthetase.