Dengue Virus Entry as Target for Antiviral Therapy

Figure 3

Location of the 2 N-glycans on the envelope protein of DENV. The DENV E-protein dimer carries 2 N-glycans on each monomer at Asn67 and Asn153. β-strands are shown as ribbons with arrows, α-helices are shown as coiled ribbons. Thin tubes represent connecting loops. Domain I is shown is red, domain II is shown in yellow and contains the fusion peptide near Asn153. Domain III is shown in blue. Disulfide bridges are shown in orange. In green, the ligand N-octyl-D-glucoside is shown, which interacts with the hydrophobic pocket between domains I and II (modified figure from Modis et al., PNAS, 2003) [100].