Host Cell Signalling and Leishmania Mechanisms of Evasion

Figure 1

Downregulation of macrophages signalling by Leishmania infection. Leishmania infection modulates phosphatases (SHP-1 and PTP-1B) activity by mechanism involving the metalloprotease gp63. SHP-1 was found to interact with IRAK-1, a key kinase involved on TLR-triggered signaling pathway. Whereas, both SHP-1 and PTP-1B are involved in the downregulation of IFNγ-induced pathway (JAK/STAT1) as well as MAPK activation. In addition, transcription factor such as NF-κB and AP-1 are cleaved/degraded in part by Leishmania gp63. Orange arrows indicate gp63 involved modulation; black arrows indicate activation; red abrogated lines indicate downregulation.