Synthesis, SAR, and Docking Studies Disclose 2-Arylfuran-1,4-naphthoquinones as In Vitro Antiplasmodial Hits

Figure 2

Retrosynthetic scheme of HNQs 6a–h, ortho-FNQs 7a–h and para-FNQs 8a–h, 2-(oxiran-2-ylmethoxy)naphthalene-1,4-dione (9), and ANQs 10a–c, starting from lawsone (5).