Anti-Onchocercal Properties of Extracts of Scoparia dulcis and Cylicodiscus gabunensis

Table 1

IC₅₀ and IC₁₀₀ values of extracts in the secondary screen for male, female, and microfilariae (mf) of Onchocerca ochengi.

Extracts Code	IC50 (μg/ml) for % inhibition of male worm motility	IC100 (μg/ml) for % inhibition of male worm motility	IC50 (μg/ml) for % inhibition of female worm	IC100 (μg/ml) for % inhibition of female worm	IC50 (μg/ml) for % inhibition of microfilariae motility	IC100 (μg/ml) for % inhibition of microfilariae motility
SDHex	50.78	62.50	50.78	62.50	3.91	7.81
SDMeC	62.5	125	60.57	125	3.91	7.81
CGMeC	50.78	62.5	62.5	125	16.28	31.25
CGHex	—	—	—	—	22.10	62.50

(SDHex: hexane extract of S. dulcis; SDMeC: methylene chloride extract of S. dulcis; CGMeC: methylene chloride extract of C. gabunensis; CGHex: hexane extract of C. gabunensis).