Convulsive and Neurodegenerative Effects in Rats of Some Isolated Toxins from the Tityus bahiensis Scorpion Venom

Table 2

Electrographic effects of injection of Tityus bahiensis scorpion venom toxins into the hippocampus. The rats had cannulae and electrodes implanted in the CA1 area of the hippocampus. The recordings were made up to 4 h after injection. The group of animals that presented a significant increase in the electrographic signs was considered as having epileptiform activity.

	Isolated spikes	Grouped spikes	Short discharge	Moderate discharge	Strong discharge
Ringer	—	—	—	—	—
Tb V-1	100%*	100%*	75%*	—	—
Tb V-5	100%*	50%*	100%*	—	—
Tb V-24	100%*	100%*	40%	25%	—
Tb V-27	100%*	80%*	83%*	20%	50%*
Tb V-28	100%*	80%*	100%*	100%*	25%

∗Significantly different from control group treated with Ringer solution; 𝑃<0.05, Fisher’s exact test.