Pleiotropic Effects of Thyroid Hormones: Learning from Hypothyroidism
Figure 4
Response to an adenosine (ADO) blocker (PSPX) in glomerular hemodynamics from normal (NL) and hypothyroid (HTX) rats. (a) The balance of glomerular blood flow (GBF), the afferent and efferent resistances (AR, ER, resp.), and the permeability of the glomerular capillary membrane (Kf) maintain a normal glomerular filtration rate (GFR). (c) Since normal glomerular hemodynamics is not importantly regulated by adenosine, the administration of an adenosine blocker does not modify the GFR. (b) In contrast, renal vasoconstrictions are observed under hypothyroid conditions. (d) The administration of an adenosine blocker completely reverses the alterations of glomerular hemodynamics in the hypothyroid kidney. White arrows are indicative of magnitude of AR or ER, whereas yellow arrows represent the magnitude of the glomerular filtration rate.
