Journal of Thyroid Research / 2011 / Article / Tab 2 / Review Article
Do Thyroid Disrupting Chemicals Influence Foetal Development during Pregnancy? Table 2 Thyroid-disrupting properties of polychlorinated biphenyls in human studies on pregnant women, neonates, infants, adolescents, and adults.
Year Author N Subjects Effect Reference 1994 Koopman-Esseboom et al. 105 Pregnant women
TT3
TT4[62 ] 105 Infants
TSH at 2 weeks and 3 months2005 Takser et al. 101 Pregnant women
TT3
TSH[58 ] 92 Cord blood No effect 2008 Wilhelm et al. 165 Pregnant women No effect [65 ] 127 Cord blood No effect 2009 Alvarez-Pedrerol et al. 1090 Pregnant women
TT3
fT4[70 ] 2009 Dallaire et al. 120 Pregnant women
T3[71 ] 95 Cord blood
TBG
fT4130 Infants, 7 months old No effect 2000 Longnecker et al. 160 Cord blood No effect [63 ] 2005 Wang et al. 118 Cord blood
T3
T4[72 ] 2008 Dallaire et al. 670 Cord blood
TBG[68 ] 2008 Herbstman et al. 289 Cord blood,
TT4
fT4[67 ] 265 Neonatal blood spot**
TT42007 Chevrier et al. 285 Newborns
TSH[66 ] 2001 Matsuura et al. 337 Breastfed infants* No effect [64 ] 2003 Ribas-Fito et al. 98 Infants Trend toward
TSH [61 ] 2010 Darnerud et al. 150 Infants
TT3[73 ] 1999 Osius et al. 320 Children
fT3
TSH[74 ] 2000 Steuerwald et al. 182 Children No effect [60 ] 2008 Alvarez-Pedrerol. 259 Children
TT3
fT4[75 ] 2005 Hsu et al. 60 Boys No effect [69 ] 2008 Schell et al. 232 Adolescents
fT4
TSH[76 ] 2001 Sala et al. 192 Adults Trend toward
TSH [77 ] 2001 Hagmar et al. 110 Adult men No effect [78 ] 2001 Hagmar et al. 182 Adult women
TT3[79 ] 2001 Persky et al. 229 Adults Female:
T4,FTI. Men
T3-uptake [80 ] 2003 Bloom et al. 66 Adults No effect [81 ] 2003 Langer et al. 101 Adults
thyroid volume[82 ] 2004 Schell et al. 115 Adults
fT4
T4
TSH2007 Tyruk et al. 2445 Adults
TT4, in older persons
TSH[83 ] 2008 Abdelouahab et al. 211 Adults Female
T3; men
T4
TSH [84 ] 2009 Dallaire et al. 623 Adults
TT3,
TBG[59 ]
PCBs were measured in blood unless otherwise stated. *PCBs measured in breast milk. **neonatal blood spot at day 18 postpartum. N : number, TSH: thyrotropin, TT3: total tri-iodothyronine, TT4: total thyroxine, fT3 free Tri-iodothyronine, fT4: free thyroxine, FTI: free T4 index, and TBG: thyroid hormone-binding globulin.