Alterations along the Hypothalamic-Pituitary-Thyroid Axis of the Zebrafish (Danio rerio) after Exposure to Propylthiouracil
Figure 7
Representative PAS-stained sagittal sections of zebrafish (Danio rerio) pituitaries exposed to PTU. The adenohypophysis is encircled by a dotted line to highlight the changes in the ratio between adeno- and neurohypophysis. A massive proliferation of PAS-positive cells (*) mostly located in the proximal pars distalis is evident. PI—pars intermedia (adenohypophysis); PN—pars nervosa (neurohypophysis); PPD—proximal pars distalis (adenohypophysis); RPD—rostral pars distalis (adenohypophysis). Sections of 2 μm thickness stained with periodic acid-Schiff (PAS) and Mayer’s hematoxylin.