Journal of Thyroid Research / 2011 / Article / Tab 1 / Review Article
Challenges in Interpretation of Thyroid Function Tests in Pregnant Women with Autoimmune Thyroid Disease Table 1 Trimester-specific reference ranges in various studies. Only a sample of studies is shown in order to exemplify the variety of values obtained in different populations of pregnant women and by different methods. Free thyroid hormone values are given—in some of the studies also total hormones have been measured together with T3 uptake to perform a free T4 index/estimate. Not all studies excluded pregnant women with thyroid autoantibodies.
TSH Free T4 Free T3 Method 1st trim 2nd trim 3rd trim 1st trim 2nd trim 3rd trim 1st trim 2nd trim 3rd trim Boas et al. [13 ] All trim Roche Modular Elecsys 0.2–3.4 0.4–3.6 0.4–4.2 12–22 10–18 10–18 3.5–6.3 3.3–5.7 3.3–5.8 Cotzias et al. [28 ] All trim ADVIA Centaur System 0–5.5 0.5–3.5 0.5–4.0 10–16 9–15.5 8–14.5 3–7 3–5.5 2.5–5.5 Dhatt et al. [32 ] All trim/Arabs Abbott Architect 0.06–8.3 0.17–5.9 0.2–6.9 8.9–24.6 8.4–19.3 8.0–18.0 ND ND ND Dhatt et al. [32 ] All trim/Asians Abbott Architect 0.12–7.4 0.3–5.5 0.3–4.9 11.3–21.9 9.7–18.5 8.9–16.6 ND ND ND Gilbert et al. [31 ] 1st trim Abbott Architect 0.02–2.2 ND ND 10–17.8 ND ND 3.3–5.7 ND ND Gong and Hoffman [34 ] All trim Roche Modular Elecsys ND ND ND 11–19 9.7–17.5 8.1–15.3 ND ND ND Lambert-Messerlian et al.* [24 ] 1st and 2nd trim Immulite 2000 0.1–2.7 0.4–2.8 ND 0.9–1.4 0.8–1.3 ND ND ND ND Larsson et al. [37 ] All trim Abbott Architect 0.1–3.4 0.4–3.4 0.4–4.0 ND ND ND ND ND ND La’ulu et al. [30 ] 2nd trim Abbott Architect i2000SR ND 0.1–3.3 ND ND 9.1–15.4 ND ND 3.8–6.0 ND Marwaha et al. [29 ] All trim Roche Modular Elecsys 0.6–5.0 0.4–5.8 0.7–5.7 12–19.5 9.5–19.6 11.3–17.7 1.9–5.9 3.2–5.7 3.3–5.2 Pearce et al. [36 ] 1st trim 0.04–3.6 ND ND ND ND ND ND ND Price et al. [33 ] 1st and 2nd trim/Asians Bayer Diagnostics ACS:180 0.6–1.3 1.0–1.8 ND 11.8–13.4 10.9–12.1 ND ND ND ND Price et al. [33 ] 1st and 2nd trim/Caucasian Bayer Diagnostics ACS:180 0.7–1.1 1.2–1.5 ND 12.0–12.8 11.2–11.8 ND ND ND ND Soldin et al. [35 ] All trim Tandem Mass Spectrometry 0.2–2.99 0.5–3.0 0.4–2.8 3.7–23.4 7.4–18.9 8.3–15.6 ND ND ND
TSH was measured in mU/L, free T4 in pmol/L, and free T3 in pmol/L. ND: not done. * the 5th and 95th percentile; free T4 in μ g/L.
