Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer

<table>Possible involvement of NKX2-1 and/or PAX8 in the maintenance and/or activity of stem cells of the thyroid. Transformation of NKX2-1 and/or PAX8-expressing stem cells leads to thyroid cancer. Transformed NKX2-1 and/or PAX8-expressing stem cells self-renew and proliferate to produce cancer. Upon becoming tumorigenic, most of transformed cells may lose NKX2-1 and/or PAX8 expression. FTC: follicular thyroid carcinoma, PTC: papillary thyroid carcinoma, and MTC: medullary thyroid carcinoma.</table>

Journal of Thyroid Research

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Figure 1

Figure 1: Thyroid-Specific Transcription Factors and Their Roles in Thyroid Cancer 