Review Article

Looking for the Mechanism of Action of Thyroid Hormone

Table 1

Multiplicity of physiological and biochemical actions of thyroid hormone.

Growth and developmental actionsMetabolic actions

Rate of postnatal growth of many mammalian and avian tissuesRegulation of basal metabolic rate in endotherms
Functional and biochemical maturation of fetal brain and boneMovement of water and Na+ ions across cell membranes
Calcium and phosphorus metabolism
Morphogenesis, gene switching, and cell death in amphibian larval metamorphosisRegulation of metabolism of cholesterol and other lipids
Control of molting in birdsNitrogen (urea, creatine) metabolism
Regulation of synthesis of mitochondrial respiratory enzymes and membranesControl of oxidative phosphorylation and energy metabolism