Challenges Associated with Tyrosine Kinase Inhibitor Therapy for Metastatic Thyroid Cancer

Figure 1

Transmission electron micrographs of endomyocardial biopsy from patient with systolic heart failure treated with a TKI. Section shows hypertrophy and interstitial edema with edematous mitochondria (open red arrow), with increased lipid droplets (solid red arrow) and dilatation of sarcotubular elements (yellow arrow). These findings are consistent with acute but reversible injury.