Changes of TSH-Stimulation Blocking Antibody (TSBAb) and Thyroid Stimulating Antibody (TSAb) Over 10 Years in 34 TSBAb-Positive Patients with Hypothyroidism and in 98 TSAb-Positive Graves’ Patients with Hyperthyroidism: Reevaluation of TSBAb and TSAb in TSH-Receptor-Antibody (TRAb)-Positive Patients
Figure 4
Clinical course of one of the 2 patients, who had TSAb-positive Graves’ hyperthyroidism and then developed TSBAb-positive hypothyroidism (Table 1, IId). A 40-year-old woman with TSAb-positive Graves’ hyperthyroidism developed TSBAb-positive hypothyroidism. She had TSAb-positive Graves’ hyperthyroidism ((a), □) with undetectable serum TSH ((b), ●) and then developed TSBAb-positive hypothyroidism ((b), ▵) with high serum TSH ((b), ●). TSAb was dominant initially ((a), □), and then TSBAb became dominant ((b), ▵). TBII ((b), ∘) reflects TSBAb- and TSAb-activity. A patient with TSAb-positive Graves’ hyperthyroidism developed TSBAb-positive hypothyroidism. She was treated with MMI and then with T4.
