Changes of TSH-Stimulation Blocking Antibody (TSBAb) and Thyroid Stimulating Antibody (TSAb) Over 10 Years in 34 TSBAb-Positive Patients with Hypothyroidism and in 98 TSAb-Positive Graves’ Patients with Hyperthyroidism: Reevaluation of TSBAb and TSAb in TSH-Receptor-Antibody (TRAb)-Positive Patients

Table 1

Changes of TSBAb (TSH-stimulation blocking antibody) and TSAb (thyroid stimulating antibody) over 10 years in 34 TSBAb-positive patients with hypothyroidism and in 98 TSAb-positive Graves’ patients with hyperthyroidism.

	(I) 34 TSBAb-positive patients with hypothyroidism		34
Ia: Positive TSBAb persisted	Continued to have hypothyroidism	17	17
Ib: TSBAb disappeared	Ib1: Recovered from hypothyroidism	13	15
	Ib2: Continued to have hypothyroidism	2
Ic: TSBAb → TSAb	TSBAb-positive hypo → Graves’ hyper	2	2
	(II) 98 TSAb-positive Graves’ patients with hyperthyroidism		98
IIa: Positive TSAb persisted	Continued to have Graves’ hyperthyroidism	10	10
IIb: Complex changes of TSAb	IIb1: Remission	1	13
	IIb2: Recurrence	12
IIc: TSAb disappeared	IIc1: Remission	60	73
	IIc2: Recurrence	13
IId: TSAb → TSBAb	Graves’ hyper → TSBAb-positive hypo	2	2

Numbers of the patients are shown.
Serial changes of TSBAb and TSAb over 10 years were studied in 34 TSBAb-positive patients with hypothyroidism (I) and in 98 TSAb-positive Graves’ patients with hyperthyroidism (II). The 34 TSBAb-positive patients with hypothyroidism were treated with thyroxine (T4) and the 98 TSAb-positive Graves’ patients with hyperthyroidism were treated with antithyroid drugs (ATDs). Half (17) (Ia) of the 34 TSBAb-positive patients with hypothyroidism (I) continued to have positive TSBAb and continued to have hypothyroidism. Ten (IIa) of the 98 TSAb-positive Graves’ patients with hyperthyroidism (II) continued to have positive TSAb and continued to have Graves’ hyperthyroidism. With the disappearance of TSBAb, recovery from hypothyroidism was noted in 13 (Ib1) (87%) of the 15 patients, in whom TSBAb had disappeared (Ib). With the disappearance of TSAb, remissions of Graves’ hyperthyroidism were noted in 60 (IIc1) (82%) of the 73, in whom TSAb had disappeared (IIc). Two of the 34 TSBAb-positive patients with hypothyroidism developed TSAb-positive Graves’ hyperthyroidism (Ic), and two of the 98 TSAb-positive Graves’ patients with hyperthyroidism developed TSBAb-positive hypothyroidism (IId).