The Role of 18F-Fluorodeoxyglucose Positron Emission Tomography in the Prognostication, Diagnosis, and Management of Thyroid Carcinoma

Table 1

A comparison of studies examining the utility of FDG-PET in detecting malignancy in cytologically indeterminate thyroid nodules.

First author (year)	No. of patients	No. of carcinoma (%)	Definition of FDG-PET positivity	Sensitivity (%)	Specificity (%)
Kresnik (2003) [28]	24	9 (37.5)	Focal uptake with SUV > 2	100	100
Mitchell (2005) [29]	24	11 (45.8)	Focal uptake	60	91
de Geus-Oei (2006) [30]	44	6 (13.6)	Focal uptake	100	66
Sebastianes (2007) [31]	42	11 (26.2)	Focal uptake	100	39
Hales (2008) [32]	15	7 (46.7)	Focal uptake with SUV > 2	57	50
Smith (2008) [33]	23	5 (21.7)	Area under SUV curve > 175.5	100	44
Traugott (2010) [34]	51*	8 (15.6)	Focal uptake	100	59
Vriens (2011) [35]	225^#	58 (25.8)	Varied	94.8	47.9

FDG-PET: fluorodeoxyglucose positron emission tomography; SUV: standardized uptake value.
*An ongoing prospective trial; ^#a meta-analysis.