Journal of Thyroid Research / 2012 / Article / Tab 1 / Clinical Study
A Risk Prediction Index for Amiodarone-Induced Thyrotoxicosis in Adults with Congenital Heart Disease Table 1 Overall cohort and group characteristics (
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=
1
6
9
).
Variable Entire cohort (
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1
6
9
) Group with AIT Group without AIT
𝑃
valueMen—
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(%) 89 (52.7) 13 (56.5) 76 (52.1) 0.69 Age (years)—mean (SD) 42.7 (14.1) 35.3 (12.2) 43.8 (14.1) 0.006 BMI (kg/m2 )—mean (SD) 25.2 (4.9) 22.0 (3.1) 25.8 (4.9) <0.001 Weight (kg)—mean (SD) 69.9 (16.5) 62.2 (11.8) 75.5 (16.5) 0.001 Supraventricular arrhythmia*—n (%) 152 (90) 23 (100) 129 (88.4) 0.084 Baseline systolic blood pressure (mm Hg)—mean (SD) 117 (13) 116 (17.5) 117.2 (12.5) 0.77 Cyanotic CHD diagnosis—
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(%) 34 (20.1) 8/23 (34.8) 26/146 (17.8) 0.059 Tricuspid regurgitation—
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(%) Absent Mild Moderate Severe 37 (25) 50 (35) 23 (16) 34 (24) 7 (37) 7 (37) 2 (10.5) 3 (15.8) 30 (24) 43 (34) 21 (16.8) 31 (24.8) 0.17** Left ventricular ejection fraction % —mean (SD) 47.5 (13.5) 43 (13.2) 48 (13.4) 0.15 Hematocrit (%)—mean (SD) 42.9 (7.2) 43.5 (4.7) 42.8 (7.5) 0.61 Protein-losing enteropathy—
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(%) 8 (4.8) 0 (0) 8 (5.5) 0.6 Goiter—
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(%) 19 (12.9) 7 (35) 12 (9.5) 0.002 Albumin (g/dL)—median (IQR) 4.3 (4.0–4.5) 4.4 (4.2–4.7) 4.3 (4–4.5) 0.13 Average amiodarone dose/day (mg/day)—median (IQR) 200 (200–300) 200 (200–250) 200 (200–300) 0.77 Average amiodarone dose/kg/day (mg/kg/day)—median (IQR) 3.04 (2.42–3.87) 3.51 (2.32–3.85) 2.96 (3.05–4.12) 0.015 Time on amiodarone (days)—median (IQR) 1147 (546–2438) 1066 (849–1470) 1206 (393–2529) 0.79 Cumulative amiodarone exposure (g/kg)—median (IQR) 3.7 (1.2–7.3) 3.5 (2.7–5.2) 3.8 (1.1–7.3) 0.60 Abnormal liver tests—
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(%) 26 (16.5) 2 (8.7) 24 (17.8) 0.27 Abnormal pulmonary function test—
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(%) 67 (84.4)*** 14 (100) 53 (81.5) 0.11 Hospital admissions per year on amiodarone****—median (IQR) 0.4 (0.2–1.1) 0.4 (0.1–1.0) 0.6 (0.2–1.1) 0.57 Days in the hospital per year on amiodarone****—median (IQR) 3.4 (1.2–8.0) 2.6 (0.9–6.4) 4.5 (1.7–13.5) 0.15
* The ventricular arrhythmias treated were ventricular tachycardia, premature ventricular contractions, and ventricular fibrillation.
**
𝑃
value for trend.
*** This variable was available in less than 75% of the entire cohort.
**** 23 age and gender matched pairs used for this analysis. BMI: body mass index; CHD: congenital heart disease.