TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis
Figure 7
Computer simulation of thyrotropic adaptation in critical illness. A gradual increase of central type 2 deiodinase activity over several days with subsequent restoration to normal values has been simulated with SimThyr using the mathematical model shown in Figure 2. Note the temporarily increased TSH values after day 17 that are occasionally observed also in vivo in patients recovering from nonthyroidal illness syndrome.
