The Role of Thyrotrophin Receptor Antibody Assays in Graves’ Disease

Table 3

Current indications for TRAb testing.

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Indications for TRAb testing

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Establishing diagnosis of GD and differentiating from other thyrotoxic states

Thyrotoxicosis complicating the Immune reconstitution syndrome (CAMPATH and HAART)

Euthyroid or unilateral orbitopathy

Orbitopathy with hypothyroidism

Pregnancy in women:

 (a) currently on ATD therapy

 (b) who have had previous ablative therapy (RAI or surgery)

 (c) with previous children who had neonatal thyrotoxicosis

In the first trimester and at 22–26 weeks gestation

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The current indications for TRAb testing are detailed above. Its use is limited to diagnostic indications. There is no clinical utility of TRAb in predicting outcome at present.