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Patient number | Age (years) | Gender | Tumor histology | Tumor stage at initial diagnosis | Primary surgical treatment | Prior THW-aided 131-I (GBq†) | Metastatic site(s) at time of first rhTSH-aided RIT | Previous EBR and/or chemotherapy (ChT) | Indication(s) for rhTSH | Number of rhTSH-aided 131-I (GBq) | Clinical effect of rhTSH-aided 131-I | Outcome | Survival after the first rhTSH-aided 131-I (months) |
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1 | 81 | F | Fo | T4N0M0 | Total thyroidectomy | 38.55 | Bone | EBR | Advanced age, potential compressive neurological symptoms | 2 | 1×PR 1×PD | Dead of other reasons | 22 |
2 | 73 | F | H | T4N0M1 | Total thyroidectomy | 27.89 | Bone, lung | EBR, ChT | Progressive paraparesis, potential additional compressive neurological and respiratory symptoms | 2 | 2×PR | Dead of other reasons | 81 |
3 | 79 | F | H | T4N0M0 | Total thyroidectomy | 39.47 | Lung | EBR | Advanced age, potential respiratory symptoms, concomitant diseases | 1 | 1×PD | Dead of metastatic disease | 15 |
4 | 63 | F | H | T4N0M1 | Total thyroidectomy | 15.65 | Lung | EBR, ChT | Potential respiratory symptoms | 5 | 4×PD 1×SD | Dead of metastatic disease | 54 |
5 | 72 | F | P, FV | T4N0M1 | Total thyroidectomy | 68.33 | Bone | EBR, ChT | Advanced age, potential compressive neurological symptoms | 3 | 3×PD | Alive | 99 |
6 | 71 | M | H | T3N0M0 | Subtotal thyroidectomy | 50.32 | Bone, lung | EBR, ChT | Advanced age, potential compressive neurological and respiratory symptoms | 2 | 2×PD | Dead of metastatic disease | 16 |
7 | 72 | F | Fo, INS | T4N0M1 | Total thyroidectomy | 29.60 | Bone | EBR, ChT | History of severe hypothyroid symptoms, hypertension, history of breast carcinoma | 4 | 4×PD | Dead of metastatic disease | 65 |
8 | 69 | F | P, FV | T4N0M0 | Total thyroidectomy | 36.04 | Bone, lung | EBR | Heart disease, potential compressive neurological and respiratory symptoms, history of severe hypothyroid symptoms | 2 | 2×PD | Dead of metastatic disease | 33 |
9 | 78 | F | H | T4N1M1 | Total thyroidectomy | 14.73 | Lung, right kidney | — | Advanced age, potential respiratory symptoms | 4 | 1×PD 2×SD 1×PD | Alive | 91 |
10 | 62 | M | P, FV | T4N1M0 | Total thyroidectomy and modified RND | 22.64 | Lung | EBR | Potential respiratory symptoms | 2 | 2×PD | Dead of metastatic disease | 46 |
11 | 82 | F | H | T3N0M0 | Total thyroidectomy | 3.88 | Mediastinum | EBR | Advanced age, history of severe hypothyroid symptoms | 2 | 1×PD | Alive | 67 |
12 | 79 | F | Fo | T3N0M0 | Total thyroidectomy | 21.46 | Bone, mediastinum, central neck compartment | EBR | Advanced age, potential compressive neurological symptoms | 1 | 1×PD | Dead of metastatic disease | 28 |
13 | 66 | F | Fo, PoD | T2N0M1 | Total thyroidectomy | 5.69 | Bone, brain | EBR, ChT | Potential neurological symptoms from metastases | 4 | 4×SD | Dead of metastatic disease | 24 |
14 | 77 | F | Fo | T3N0M0 | Total thyroidectomy | 3.58 | Lung | — | Advanced age, heart disease | 3 | 3×SD | Alive | 81 |
15 | 64 | M | Fo | T4N0M0 | Total thyroidectomy | 0 | Mediastinum, central neck compartment | EBR | Heart disease, etilic hepatopathy, potential compressive respiratory symptoms | 1 | 1×PD | Dead of other reasons | 22 |
16 | 58 | M | P, PoD | T4N0M0 | Total thyroidectomy and prophylactic mRND | 32.93 | Bone, lung | EBR | Potential compressive neurological and respiratory symptoms | 2 | 2×PD | Dead of metastatic disease | 27 |
17 | 37 | M | P | T4aN1bM1 | Total thyroidectomy and modified RND | 3.70 | Lung | EBR, ChT | Potential respiratory symptoms | 4 | 4×SD | Alive | 74 |
18 | 83 | M | Fo | T3N0M1 | Total thyroidectomy | 35.00 | Bone, liver | — | Advanced age, potential compressive neurological symptoms, concomitant diseases | 1 | 1×SD | Alive | 61 |
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