Microchimerism in Graves' Disease

Table 1

Summary of the main experimental and clinical findings of Graves' disease and microchimerism.

Thyroid tissue origin	Storage	N	Gene and technique	Presence of microchimeric cells (%)	Reference
Graves' disease	Paraffin-embedded	20	SRY gene by ELISA-PCR	20%	Ando et al. [11]
	Frozen	7	SRY gene by ELISA-PCR	86%	Ando et al. [11]
	Paraffin-embedded	15	X and Y chromosomes by FISH	40%	Renné et al. [14]
Thyroid adenoma	Paraffin-embedded	6	SRY gene by ELISA-PCR	0%	Ando et al. [11]
	Frozen	4	SRY gene by ELISA-PCR	25%	Ando et al. [11]
	Paraffin-embedded	9	X and Y chromosomes by FISH	22%	Renné et al. [14]
Hashimoto’s thyroiditis	Paraffin-embedded	25	X and Y chromosomes by FISH	60%	Renné et al. [14]

SRY: sex-determining region Y; PCR: polymerase chain reaction; FISH: fluorescence in situ hybridization.