Frequency of Adverse Events of Antithyroid Drugs Administered during Pregnancy

Table 1

The ages and initial dose of the patients treated with antithyroid drug who developed and did not develop adverse events.

			Age, yr		Initial dose (mg/day)
	No. of patients		Mean ± SD		Median		Range
	MMI	PTU	MMI	PTU	MMI	PTU	MMI	PTU
Without adverse events	35	46	29.7 ± 4.9	32.1 ± 4.7	30	300	10~45	50~450
With adverse events	5	5	29.2 ± 2.7	33.3 ± 4.2	30	200	15~30	150~300
P value			n.s.	n.s.	n.s.	n.s.

There were no significant differences between maternal age and the starting dose of ATD (MMI and PTU) in the group that developed adverse events and the group that did not develop adverse events.
There was no significant difference in frequency of adverse events between MMI and PTU.