Modulating Thyroid Hormone Levels in Adult Mice: Impact on Behavior and Compensatory Brain Changes

Figure 3

Effects of the treatments on food/water consumption, body weight, and blood glucose levels. Body weight was monitored in both males (a) and females (b) during the course of treatment. Thyroxine treatment did not affect weight until after 15 weeks of treatment, after which the mice quickly lost weight. PTU/Met-treated mice lost a bit of weight in the first week, then maintained their weight for the duration of the study. Food (c) and water (d) consumption were significantly increased in thyroxine-treated mice (at three months of treatment). N = 4 cages/treatment group. (e) Both fasting and nonfasting blood glucose levels were significantly lower in thyroxine-treated mice. Fasting blood glucose was increased in PTU/Met-treated mice, although nonfasting glucose was unaffected. (f) Heart weight was significantly increased in thyroxine-treated mice and decreased in PTU/Met-treated mice. compared with control animals. Control = 7 M/6 F, thyroxine = 5 M/5 F (heart), and PTU/Met = 5 M/8 F. .

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