Research Article

Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy

Table 2

Highest differentially expressed genes from whole genome Microarray analysis.

GSGene nameGene molecular function/Gene biological processFDRFCUp/Down

ANKRD22Ankyrin repeat domain 22Data not found04.5 Up
BATF2Basic leucine zipper transcription factor, ATF-like 2DNA binding and transcription factor activity02.6 Up
CD38CD38 moleculeHydrolase activity in hydrolyzing N-glycosyl compounds and lyase activity02.1 Up
DCLRE1BDNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)Nucleobase, nucleoside, nucleotide, and nucleic acid metabolic process01.9 Up
EGR1Early growth response 1RNA binding, DNA binding, and transcription factor activity04.9 Up
EPSTI1Epithelial stromal interaction 1 (breast)Data not found03.2 Up
FAM26FFamily with sequence similarity 26, member FData not found02.6 Up
FCGR1BFc fragment of IgG, high affinity Ib, receptor (CD64)Receptor activity02.8 Up
FLJ11783Data not foundData not found00.4Down
GNB4Guanine nucleotide binding protein (G protein), beta polypeptide 4GTPase activity and protein binding02.3 Up
IFI44Interferon-induced protein 44Data not found03.1 Up
IFI44LInterferon-induced protein 44-likeData not found04.8 Up
IFI6In multiple clustersImmune system process02.9 Up
IFIT1Interferon-induced protein with tetratricopeptide repeats 1Response to interferon-gamma and response to stimulus07.1 Up
IFIT2Interferon-induced protein with tetratricopeptide repeats 2Response to interferon-gamma and response to stimulus04.8 Up
IFIT3Interferon-induced protein with tetratricopeptide repeats 3Response to interferon-gamma and response to stimulus07.4 Up
IFITM2Interferon-induced transmembrane protein 2 (1-8D)Immune system process02.9 Up
IFITM3Interferon-induced transmembrane protein 3 (1-8U)Immune system process02.6 Up
IFITM4PLeukocyte Ig-like receptor, subfamily A (with TM domain), member 2Data not found22.0 Up
ISG15Leukocyte Ig-like receptor, subfamily A (with TM domain), member 5Ligase activity, apoptosis, and protein metabolic process24.4 Up
LY6ELymphocyte antigen 6 complex, locus EData not found02.8 Up
MMP8Matrix metallopeptidase 8 (neutrophil collagenase)Peptidase activity and protein metabolic process05.2 Up
MX1Influenza virus resistance 1, IFN-inducible protein p78 (mouse)GTPase activity, protein binding, intracellular protein transport, and endocytosis03.0 Up
OAS2 2 - 5 -oligoadenylate synthetase 2, 69/71 kDaNucleotidyltransferase activity, nucleic acid binding, response to interferon-gamma, and response to stimulus03.2 Up
PLAC8Placenta-specific 8Data not found03.0 Up
PLSCR1Phospholipid scramblase 1Immune system process, lipid transport, lipid metabolic process, and blood coagulation02.4 Up
RSAD2Radical S-adenosyl methionine domain containing 2Data not found05.6 Up
SCARB2Scavenger receptor class B, member 2Macrophage activation, lipid transport, apoptosis, signal transduction, cell adhesion, lipid metabolic process02.3 Up
SIGLEC1Sialic acid binding Ig-like lectin 1, sialoadhesinB cell mediated immunity, signal transduction, cell-cell adhesion, and response to stimulus07.8 Up
CXCL10Chemokine (C-X-C motif) ligand 10Macrophage activation, cell-cell signaling, cell motion, signal transduction, and cellular defense response13.4 Up
EIF2AK2Eukaryotic translation initiation factor 2-alpha kinase 2Immune system process, cell cycle, protein metabolic process, and response to stress12.1 Up
LAP3Leucine aminopeptidase 3Protein metabolic process13.0 Up
LCP1Lymphocyte cytosolic protein 1 (L-plastin)Structural constituent of cytoskeleton, cytoskeletal protein binding, and cellular component morphogenesis11.9 Up
SECTM1Secreted and transmembrane 1Data not found11.9 Up
SERPING1Serpin peptidase inhibitor, clade G, member 1, (Angioedema)Protein binding, peptidase inhibitor activity, and protein metabolic process13.0 Up
STXBP2Syntaxin binding protein 2Neurotransmitter secretion, intracellular protein transport, exocytosis, and synaptic transmission12.1 Up
SULT1A1Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1Transferase activity, sulfur metabolic process, and lipid metabolic process12.1 Up
TBRG1Transforming growth factor beta regulator 1Receptor binding10.4Down
BLOC1S1Biogenesis of lysosome-related organelles complex-1, subunit 1DNA binding and transcription factor activity21.9 Up
BST2Bone marrow stromal cell antigen 2Data not found22.0 Up
CCDC84Coiled-coil domain containing 84Data not found20.4Down
CDC14ACDC14 cell division cycle 14 homolog A (S. cerevisiae)Mitosis, phosphate metabolic process, and protein metabolic process20.5Down
FLJ32679In multiple clustersData not found20.5Down
FLJ38379Hypothetical protein FLJ38379Data not found20.4Down
HERC5Hect domain and RLD 5Protein metabolic process, ectoderm development, mesoderm development, and skeletal system development23.6 Up

GS: Gene Symbol; FDR: false discovery rate; FC: fold change; Up/Down: regulation in advanced versus normal or mild CAV.