Gene Expression Signatures of Peripheral Blood Mononuclear Cells during the Early Post-Transplant Period in Patients Developing Cardiac Allograft Vasculopathy

Table 3

Gene ontology categories enriched by genes expressed differentially between patients with and without advanced CAV.

Regulation in Adv-CAV	Number of genes	GO category type	Exemplary GO categories
Up-/Down-regulated	291	Biological process	GO:0006955 immune response
			GO:0002376 immune system process
			GO:0051707 response to other organism
			GO:0009607 response to biotic stimulus
			GO:0006954 inflammatory response
			GO:0050896 response to stimulus
			GO:0009615 response to virus
			GO:0009611 response to wounding
			GO:0006952 defense response
			GO:0045087 innate immune response
			GO:0009605 response to external stimulus
			GO:0042116 macrophage activation
			GO:0006950 response to stress
		Molecular function	GO:0045408 regulation of interleukin-6 biosynthetic process
			GO:0007249 I-kappaB kinase NF-kappaB cascade
			GO:0007243 protein kinase cascade
			GO:0007009 plasma membrane organization and biogenesis
			GO:0032635 interleukin-6 production
			GO:0042226 interleukin-6 biosynthetic process
			GO:0045410 positive regulation of interleukin-6 biosynthetic process
			GO:0009057 macromolecule catabolic process
			GO:0009595 detection of biotic stimulus
			GO:0007250 activation of NF-kappaB-inducing kinase
Up-Regulated	170	Biological process	None
		Molecular function	None
Down-Regulated	123	Biological process	GO:0006955 immune response
			GO:0002376 immune system process
			GO:0051707 response to other organism
			GO:0009607 response to biotic stimulus
			GO:0006954 inflammatory response
			GO:0050896 response to stimulus
			GO:0009615 response to virus
			GO:0009611 response to wounding
			GO:0006952 defense response
			GO:0045087 innate immune response
			GO:0009605 response to external stimulus
			GO:0042116 macrophage activation
			GO:0006950 response to stress
			GO:0048518 positive regulation of biological process
			GO:0002250 adaptive immune response
		Molecular function	GO:0045408 regulation of interleukin-6 biosynthetic process
			GO:0007249 I-kappaB kinase NF-kappaB cascade
			GO:0007243 protein kinase cascade
			GO:0007009 plasma membrane organization and biogenesis
			GO:0032635 interleukin-6 production
			GO:0042226 interleukin-6 biosynthetic process
			GO:0045410 positive regulation of interleukin-6 biosynthetic process
			GO:0009057 macromolecule catabolic process
			GO:0009595 detection of biotic stimulus
			GO:0007250 activation of NF-kappaB-inducing kinase
			GO:0045084 positive regulation of interleukin-12 biosynthetic process

Adv-CAV: advanced cardiac allograft vasculopathy.