Research Article

High-Dose Chemotherapy with Autologous Hematopoietic Stem-Cell Rescue for Pediatric Brain Tumor Patients: A Single Institution Experience from UCLA

Table 4

Toxicity.

Patient numberInfectious complicationsGI mucositis Liver, transaminitis (hyperbilirubinemia)Metabolic/renalOther

1Grade 4, F&NGrade 3Grade 3 (Grade 3)Grade 4
(elevated BUN/Creatinine)
Neuro: Grade 3, Altered mental status
Cardiovascular: Grade 4, Hypotension
Pulmonary: Grade 4, Respiratory failure
Skin: Grade 4, TEN
2Grade 3, F&NGrade 3
3Grade 3, F&NGrade 3Grade 3
4Grade 3, F&N, Herpetic stomatitisGrade 3Endo: Exacerbation of baseline panhypopituitarism
5Grade 3, F&N
6Grade 3, F&N, Serratia UTIGrade 3Grade 4, HypokalemiaCV: Grade 1, Prolonged QTC
Neuro: Grade 3, Hearing loss
7Grade 3, Fever, sepsis with Pseudomonas and KlebsiellaGrade 3
8Grade 3, F&N, UTI with Vancomycin-resistant enterococcusGrade 3Grade 2Neuro: Grade 2, Self-resolved seizure
9Grade 3, F&NGrade 3
10Grade 1, Decreased GFRNeuro: Grade 1,
High-frequency hearing loss
11Grade 3, F&N,
Eenterococcus UTI
Grade 3
12Grade 1, HypomagnesemiaNeuro: Grade 1,
High frequency hearing loss
13Grade 3, PneumoniaGrade 3Grade 1, Hypokalemia Grade 3, Hyponatremia (not SIADH)
14Grade 2, Fever
Grade 3, F&N
Grade 2 (Grade 3)Neuro: Grade 4, Status epilepticus
15Grade 1, Hypomagnesemia
16
17Grade 3, F&NGrade 1, Hypomagnesemia
18Grade 3, Zoster infection

F&N: Fever and neutropenia, UTI: Urinary tract infection, GFR: Glomerular filtration rate, SIADH: Syndrome of inappropriate antidiuretic hormone hypersecretion, TEN: Toxic epidermal necrolysis.