High-Dose Chemotherapy with Autologous Hematopoietic Stem-Cell Rescue for Pediatric Brain Tumor Patients: A Single Institution Experience from UCLA

Table 5

Comparison of nonneurological toxicity of three studies.

Study	IA/BBBD for embryonal/germ cell tumors/Jahnke et al. [29]	High-dose chemotherapy and autologous transplantation for sPNETs/Fangusaro et al. [8]	Current series
Number of patients	54	43	18
Hematopoietic	~35%	100%	100%
Fever and neutropenia	24%	70%	60%
Mucositis	—	Frequent in patients; receiving; methotrexate	56%
Toxic mortality	—; (No IA/BBBD treatment-related deaths were reported; all 3 patients who died from delayed neurotoxicity received CSI).	5%; (infection associated)	6%; (multiorgan failure)

IA/BBBD: Intra-arterial Chemotherapy and Osmotic Blood-Brain Barrier Disruption.
sPNETs: supratentorial Primitive Neuroectodermal Tumors.
CSI: Cerebrospinal Irradiation.