Research Article
High-Dose Chemotherapy with Autologous Hematopoietic Stem-Cell Rescue for Pediatric Brain Tumor Patients: A Single Institution Experience from UCLA
Table 5
Comparison of nonneurological toxicity of three studies.
| Study | IA/BBBD for embryonal/germ cell tumors/Jahnke et al. [29] | High-dose chemotherapy and autologous transplantation for sPNETs/Fangusaro et al. [8] | Current series |
| Number of patients | 54 | 43 | 18 | Hematopoietic | ~35% | 100% | 100% | Fever and neutropenia | 24% | 70% | 60% | Mucositis | ā | Frequent in patients receiving methotrexate | 56% | Toxic mortality | ā (No IA/BBBD treatment-related deaths were reported; all 3 patients who died from delayed neurotoxicity received CSI). | 5% (infection associated) | 6% (multiorgan failure) |
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IA/BBBD: Intra-arterial Chemotherapy and Osmotic Blood-Brain Barrier Disruption. sPNETs: supratentorial Primitive Neuroectodermal Tumors. CSI: Cerebrospinal Irradiation.
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