Thymoglobulin Induction Dosing Strategies in a Low-Risk Kidney Transplant Population: Three or Four Days?

Table 3

Various rATG dosing regimens.

Author, Center	Study Design	Organ	rATG Regimen	Control
Brennan, Barnes-Jewish, Wash U [3]	Prospective, Randomized, Double-blinded	K	1.5 mg/kg $\times$ 7days, total 10.5 mg/kg ($n=\mathrm{\hspace{0.17em}\hspace{0.17em}}48$)	Atgam 15 mg/kg $\times$ 7d($n=24$)
Agha, Barnes-Jewish, Wash U [4]	Prospective, Nonrandomized	K	3.0 mg/kg/day, then 1.5 mg/kg $\times$ 2 days, total 6 mg/kg ($n=40$)	1.5 mg/kg $\times$ 7d, total 10.5 mg/kg($n=\mathrm{\hspace{0.17em}\hspace{0.17em}}48$)
Peddi, U of Cincinnati [5]	Prospective, Single-group	High risk K, KP	1.5 mg/kg, Intermittent dosing, based on CD3^+monitoring, mean total 4.2 mg/kg ($n=41$)	Uncontrolled
Starzl, Pittsburg[6]	Prospective, Single-group	K, P, L	~5 mg/kg $\times$ 1 dose, total 5 mg/kg ($n=82$)	Uncontrolled
Stratta, Wake Forest [7]	Retrospective, Single group	P	1.5 mg/kg, Alternate-day therapy until calcineurin inhibitor levels are achieved, mean total 5.4 mg/kg ($n=55$)	Uncontrolled
Wong, Massachusetts General Hospital [8]	Prospective	K	1.0 mg/kg $\times$ 3 day, total 3 mg/kg ($n=7$)	1.5 mg/kg $\times$ 3 d, total 4.5 mg/kg ($n=9$)
Gurk, U of Maryland [9]	Retrospective cohort	High risk K	Target 1.5 mg/kg $\times$ 7-10day< 7.5 mg/kg ($n=33$)	>7.5 mg/ kg ($n=64$)
Stevens, U of Nebraska [10]	Prospective, Randomized	K	6 mg/kg $\times$ 1 dose ($n=70$)	1.5 mg/kg qod $\times$ 4 doses, total dose 6 mg/kg ($n=72$)

Abbreviations: K, kidney, P, pancreas, L, liver, KP, kidney pancreas.