Review Article

The Factors That May Predict Response to Rituximab Therapy in Recurrent Focal Segmental Glomerulosclerosis: A Systematic Review

Table 1

Demographic characteristics of renal transplant patients with recurrence FSGS that received rituximab. Values expressed as median (range) or proportion (%).

VariableResults

Age at diagnosis (years)6 (1–40)
Age at transplant (years)18 (5–48)
Time to end stage renal disease (years)3 (0.16–19)
Recipient male22/39 (56.4)
Deceased donor transplant26/39 (66.7)
Time to relapse of FSGS (days)3 (1–3513)
Serum albumin at relapse (g/dL)2.5 (1.2–4.4)
Proteinuria at relapse (g/day)6.2 (1.1–97.4)
Diagnosis of PTLD3/39 (7.7)
Number of plasmapheresis treatments21 (0–133)
Number of rituximab doses4 (1–6)
Complete response to therapy17/39 (43.5)
Time to response from rituximab (months)2 (0.63–12)