Cyclosporine: A Commentary on Brand versus Generic Formulation Exchange

Table 1

Cyclosporine development timeline.

Date	Significant event
November 1983	Sandimmune (cyclosporine) oral solution approval
March 1990	Sandimmune (cyclosporine) capsule approval
July 1995	Neoral capsules and solution approval (brand cyclosporine modified)
October 1998	SangStat’s SangCya (generic cyclosporine modified) approval
January 2000	Cyclosporine modified capsules (Sandoz) approval
May 2000	Cyclosporine modified capsules (Gengraf, Abbott)
December 2000	SangCya withdrawal
December 2000	Cyclosporine modified capsules (Pliva) approval
December 2001	Cyclosporine modified solution (Pliva) approval
May 2002	Cyclosporine capsules (generic Sandimmune, Apotex) approval
September 2004	Cyclosporine solution (generic Sandimmune, Morton Grove) approval
January 2005	Cyclosporine modified solution (Novex) approval
March 2005	Cyclosporine modified capsules and solution (Ivax) approval