Impact of Acute Rejection on Kidney Allograft Outcomes in Recipients on Rapid Steroid Withdrawal
Table 3
Characteristics of Acute rejections.
SR
CR
value
Days to biopsy proven rejection (median, 25–75%)
130 (111–361)
19 (10.5–146)
<.05
Serum creatinine at biopsy in μmol/L (mean ± SD)
<.001
Tacrolimus level in ng/mL at time of biopsy (mean ± SD)
Mycophenolate mofetil dose in mg/day at time of biopsy (mean ± SD)
Banff grade of rejection
*
Borderline
18 (39%)
4 (11%)
Ia
16 (35%)
11 (31%)
Ib
5 (11%)
11 (31%)
IIa
4 (9%)
4 (11%)
IIb
III
1 (2%)
AMR
2 (4%)
5 (14%)
Peritubular C4d staining
C4d positive
10/34 (29%)
6/31 (19%)
Chronic changes
IFTA > 2 at Bx
43%
24%
SR: subclinical rejection, CR: clinical rejection, AMR: antibody mediated rejection, IFTA: interstitial fibrosis and tubular atrophy (sum of Banff ci plus ct score).
* For the difference in the overall Banff classification of rejection by chi-square test.
