β-Cell Generation: Can Rodent Studies Be Translated to Humans?

Figure 1

Section of murine pancreas stained with anti-insulin (red) and anti-BrdU (brown) antibodies. C57BL/6 mice were on a high-fat diet for 6 weeks. BrdU was injected for one week by s.c. injections, thereby labeling all proliferating cells. A number of replicating β-cells (arrows) and acinar cells are detected.