A Prospective, Multinational Pharmacoepidemiological Study of Clinical Conversion to Sirolimus Immunosuppression after Renal Transplantation

Table 3

Cox analysis of time to rejection, graft loss, or death following renal transplantation.

Covariates	Time to acute rejection			Time to graft loss			Time to death
	HR	95% CI	𝑃	HR	95% CI	𝑃	HR	95% CI	𝑃
Conversion before or after 1 year	6.604	(2.145, 20.33)	0.0010	1.185	(0.634, 2.216)	0.5949	1.287	(0.507, 3.268)	0.5958
Recipient age (years)	0.969	(0.939, 1.000)	0.0511	0.985	(0.967, 1.004)	0.1190	1.069	(1.030, 1.110)	0.0004
Recipient race (Black versus non-Black)	1.178	(0.377, 3.686)	0.7781	1.627	(0.777, 3.403)	0.1965	0.870	(0.251, 3.022)	0.8271
Prior kidney transplant (yes versus no)	0.979	(0.213, 4.500)	0.9783	1.527	(0.611, 3.817)	0.3655	3.023	(0.783, 11.67)	0.1084
Current PRA	0.995	(0.929, 1.066)	0.8877	0.980	(0.932, 1.030)	0.4278	0.980	(0.920, 1.043)	0.5207
Anti-CD25 induction therapy versus none	3.707	(1.276, 10.77)	0.0160	1.174	(0.528, 2.607)	0.6941	1.307	(0.412, 4.144)	0.6497
ATG/OKT3 induction therapy versus none	1.363	(0.444, 4.181)	0.5880	1.118	(0.573, 2.179)	0.7438	0.696	(0.241, 2.009)	0.5033
Donor organ: cadaver versus living	1.979	(0.375, 2.553)	0.9654	1.306	(0.731, 2.333)	0.3666	2.711	(0.893, 8.235)	0.0785