Islet -Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest
Figure 1
HGF, Pax4, GIP, and LRH-1 increase β-cell regeneration and preservation. Schematic representation of the putative interactions among HGF, GIP, Pax4, and LRH-1 that impact β-cell survival and expansion. (a) These factors regulate common pathways and targets such as NF-B and bcl-2 that exert beneficial effects on β-cells. (b) HGF and Pax4 promote transdifferentiation from other pancreatic cells to β-cells in addition to enhancing β-cell survival and function.