Review Article

Islet 𝜷 -Cell Mass Preservation and Regeneration in Diabetes Mellitus: Four Factors with Potential Therapeutic Interest

Figure 1

HGF, Pax4, GIP, and LRH-1 increase β-cell regeneration and preservation. Schematic representation of the putative interactions among HGF, GIP, Pax4, and LRH-1 that impact β-cell survival and expansion. (a) These factors regulate common pathways and targets such as NF- 𝜅 B and bcl-2 that exert beneficial effects on β-cells. (b) HGF and Pax4 promote transdifferentiation from other pancreatic cells to β-cells in addition to enhancing β-cell survival and function.
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(a)
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(b)