The Hepatoprotective Effect of Sodium Nitrite on Cold Ischemia-Reperfusion Injury

Figure 7

Caspase-3 concentrations decreased with nitrite supplemented solutions. Caspase-3 concentrations increased during cold preservation with both LR (18 hours) and UW solutions (48 hours) alone, but were significantly attenuated when the respective solutions were supplemented with 250 μM of anion nitrite (LR—49.1±3.7 versus LR + nitrite—38.6±3.7; UW—71.4±4versus UW + nitrite 50.4±3.1). Supplemented UW solution demonstrated the greatest attenuation. Data are expressed as mean ± SE. ^#𝑃<0.05 for corresponding measurements that compared groups LR and UW only to native B6 and ^†𝑃<0.05 for corresponding measurements that compared groups LR and UW only to LR and UW groups treated with anion nitrite.