Table 1: miRNAs expressed in islets treated in vitro with a cocktail of IL-1β, IFN-γ, and TNF-α were identified by SAM of global miRNAs. The score ( 𝑑 ) represents value of the T-statistic; a higher score means a greater difference between the two groups. 𝑞 -values correspond to the 𝑃 values adapted to the analysis of a large number of genes. FI and SD are fold increase and standard deviation of hybridization values (cytokine versus control), respectively.

Upregulated miRNAs( 𝑑 ) 𝑞 (%)FISDmiRNA( 𝑑 ) 𝑞 (%)FISD

miR-1436.707.53.5miR-27a4.506.24.2
miR-30e6.0015.311.4let-7a4.408.47.1
miR-1826.009.14.8miR-3754.407.86.4
miR-966.0013.69.4miR-30a4.405.33.3
miR-1415.9013.210.6miR-19b4.306.64.5
miR-245.709.26.2let-7f4.3019.825.4
miR-29b5.5012.711.2miR-164.104.72.9
miR-2125.509.87.0miR-29c4.1010.610.2
miR-7a5.2010.78.6miR-1034.103.00.9
miR-19a5.203.91.3miR-148b-3p4.007.16.1
let-7i5.2013.79.6miR-30d3.904.12.3
miR-1535.1025.027.8miR-301a3.9022.326.5
miR-225.104.71.9let-7c3.905.13.5
miR-27b5.008.15.7miR-23b3.804.32.5
miR-215.0010.26.5miR-29a3.705.84.5
miR-30b-5p5.006.64.2miR-23a3.604.32.6
let-7d4.909.67.7miR-2043.607.48.2
miR-30c4.806.54.0miR-5412.9013.116.0
miR-200a4.8013.011.5miR-99b2.9013.11.3
miR-2074.804.62.2rno-let-7b2.803.62.3
miR-1834.804.72.0miR-125b-5p2.703.01.7
miR-1274.807.63.8miR-17/17-5p2.709.914.2
miR-1074.706.03.7miR-1942.502.91.8
miR-3354.702.80.7miR-200c2.402.61.4
miR-101a4.703.92.7miR-125a-5p2.402.61.5
miR-26a4.706.54.5miR-200b2.302.71.5
miR-984.609.37.8miR-340-5p2.202.31.1
miR-7b4.6014.013.4let-7e2.002.31.1
miR-1264.504.52.2miR-3372.002.02.3
miR-106b4.504.01.5

Downregulated miRNAs( 𝑑 ) 𝑞 (%)FISD

miR-185 −2.8 04.03.3
miR-129 −3.0 02.81.5
miR-503 −3.2 04.13.2
miR-370 −3.4 03.52.1
miR-206 −4.3 02.60.7