Clinical Study

Evaluation of Protocol Biopsy Utility 12 Months after Renal Transplantation: A Multicenter Observational Analysis

Table 4

Histological results of surveillance biopsies at one year posttransplant (central reading) among adequate samples ( 𝑛 = 1 1 6 ).

Histological lesionsGrade 𝑁 (%)

No significant changes (normal kidney graft)51 (44)
Acute antibody-mediated rejection0
Chronic antibody-mediated rejection2 (1.8)
Acute cellular rejectionI B2 (1.8)
Chronic cellular rejection2 (1.8)
C4d+3 (3)

Glomerulitis (g)0102 (87.9)
18 (6.9)
24 (3.4)
32 (1.7)

Peritubular capillaritis (ptc) 098 (85.2)
19 (7.8)
27 (6.1)
31 (0.9)

Acute tubular necrosis12 (10.3)
IF/TA (Grade II and III)35 (30.2)
CNI-related toxicity15 (12.9)
Recurrence of initial disease2 (1.7)
BK virus nephropathy1 (0.9)
Thrombotic microangiopathy3 (2.6)

IF/TA: interstitial fibrosis/tubular atrophy.