Medical Gases: A Novel Strategy for Attenuating Ischemia—Reperfusion Injury in Organ Transplantation?

Figure 2

Toll-like receptor (TLR): mediated pathway during IRI. Ligation of the TLR leads to activation of upstream MyD88 and activation downstream NF-κB, p38 and JNK pathways resulting in cellular injury. SEC: sinusoidal endothelial cells, DAMP: damage-associated molecular proteins [10].